The current status of human laryngeal transplantation in 2017: A state of the field review

@article{Krishnan2017TheCS,
  title={The current status of human laryngeal transplantation in 2017: A state of the field review},
  author={Giri Krishnan and Charles Du and J. Fishman and A. Foreman and D. Lott and G. Farwell and P. Belafsky and S. Krishnan and M. Birchall},
  journal={The Laryngoscope},
  year={2017},
  volume={127}
}
Human laryngeal allotransplantation has long been contemplated as a surgical option following laryngectomy, but there is a paucity of information regarding the indications, surgical procedure, and patient outcomes. Our objectives were to identify all human laryngeal allotransplants that have been undertaken and reported in the English literature and to evaluate the success of the procedure. 
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References

SHOWING 1-10 OF 65 REFERENCES
Risk Acceptance in Laryngeal Transplantation
TLDR
A questionnaire‐based survey was used to measure the degree of risk individuals are willing to accept to receive different types of transplantation procedures, and the risks versus benefits in larynx transplantation. Expand
A 12-year perspective on the world's first total laryngeal transplant.
TLDR
This effort represents the longest continuous survival of a first organ transplant, when an immunosuppressive regimen was used. Expand
What is the future of ‘organ transplantation’ in the head and neck?
  • D. Lott
  • Medicine
  • Current opinion in otolaryngology & head and neck surgery
  • 2014
TLDR
Significant advancements in tissue engineering have occurred, including the ability to generate three-dimensional tissue structures, which set the foundation to expand reconstructive options for dysfunctional tissues and to improve a patient's quality of life. Expand
Laryngeal transplantation: research, clinical experience, and future goals.
TLDR
Investigations into the use of irradiation, single-drug and multidrug immunosuppression, and the effects of mammalian target of rapamycin (mTOR) inhibitors have produced significant insight into laryngeal allograft preservation. Expand
Laryngeal transplantation and 40-month follow-up.
Total laryngectomy and total occlusion of the larynx with tracheostomy are associated with an impaired sense of taste and smell, an increased incidence of tracheobronchial infections, stomalExpand
Management of larynx and trachea donors.
TLDR
These donors may have differences from other multiorgan donors: (1) they do not require strict fluid management; (2) vasoactive agents may be used in higher doses than in organ donors, and the larynx tolerates hemodynamic instability. Expand
Transplantation of the larynx--a case report that speaks for itself.
  • A. Monaco
  • Medicine
  • The New England journal of medicine
  • 2001
TLDR
This thoughtfully executed application of laryngeal transplantation, initiated after a series of careful experimental studies, is a wonderful example of bench-to-bedside research for which the authors are to be commended. Expand
Laryngeal and tracheal transplantation: ethical limitations.
Over the last decade, there have been extraordinary developments in the field of transplantation science. As a result, organ transplantation enjoys a success that is unparalleled since itsExpand
Laryngeal transplantation: ethical considerations.
TLDR
Recent advances in immunosuppression, graft preservation techniques, and an understanding of the cellular mechanisms of allograft rejection have diminished the risk of this therapeutic modality and warrant reconsideration of the ethics of laryngeal transplantation in the context of current scientific knowledge. Expand
Laryngeal replacement with an artificial larynx after total laryngectomy: The possibility of restoring larynx functionality in the future
Most patients perceive total laryngectomy as a mutilation carrying with it a loss of physical and psychological integrity. Thus, an artificial larynx system that can replace the laryngeal functionsExpand
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