The current status of human laryngeal transplantation in 2017: A state of the field review

  title={The current status of human laryngeal transplantation in 2017: A state of the field review},
  author={Giri Krishnan and Charles Du and Jonathan M. Fishman and Andrew Foreman and David G. Lott and Gregory Farwell and Peter C Belafsky and Suren Krishnan and Martin A. Birchall},
  journal={The Laryngoscope},
Human laryngeal allotransplantation has long been contemplated as a surgical option following laryngectomy, but there is a paucity of information regarding the indications, surgical procedure, and patient outcomes. Our objectives were to identify all human laryngeal allotransplants that have been undertaken and reported in the English literature and to evaluate the success of the procedure. 

A New Animal Model of Laryngeal Transplantation

A reliable and reproducible animal model for laryngeal transplantation is presented, with quality of revascularisation of the transplant being the principal objective and optimised of the various steps of the procedure, with the integration of a new reinnervation technique as a secondary objective.

Voice Rehabilitation after Total Laryngectomy

No evidence-based consensus exists on which voice rehabilitation method is best for improving the patient’s quality of life, so this review aims to summarize the current voice rehabilitation and management of voice prosthesis after total laryngectomy.

Upper extremity and craniofacial vascularized composite allotransplantation: ethics and immunosuppression.

This article will focus on upper extremity and craniofacial VCA, beginning with a brief review of the history of VCA including reported outcomes, followed by a discussion of the range of ethical concerns, before exploring in greater detail how immunological issues inform and shape several of the ethical concerns.

How to Help Patients Considering VCA.

Patients who might benefit from some form of vascularized composite allotransplantation (VCA) can be expected to have prior long-standing relationships with one or more primary care professionals or

Attitudes of Hand Surgeons and Hand Reconstruction Patients Toward Hand Allotransplantation in Taiwan.

There is support for hand allotransplantation as a solution for limb loss in both hand surgeons and hand patients in Taiwan, although further work is required to assess the willingness of broader Taiwanese medical to refer candidates and for the general population to donate.

Large Animal Models of Vascularized Composite Allotransplantation: A Review of Immune Strategies to Improve Allograft Outcomes

This comprehensive review of recent immune strategies undertaken to improve VCA outcomes with a focus on relevant preclinical large animal models highlights major advancements made utilizing large animal VCA models.

A Call to Accountability: Reporting Outcomes in Vascularized Composite Allotransplantation

This paper encourages the American Society of Reconstructive Transplantation and the Organ Procurement and Transplant Network committee to embrace the international ethical standards and to hold all vascularized composite allotransplant programs in the United States accountable for reporting data on outcomes of pre-September 2015 transplants.

TRRM_A_161961 39..46

The current evidence to assess the sociocultural and demographic factors that influence the growth and success of VCA procedures is reviewed.

Functional identification of abductor and adductor branches for laryngeal transplantation

This study shows a way of reinnervation of a transplanted larynx which might result in a functional organ and describes the first step of the procedure: functional identification of the abductor and adductor branches of the recurrent laryngeal nerve in the donor before the l throat is excised for transplantation.



Risk Acceptance in Laryngeal Transplantation

A questionnaire‐based survey was used to measure the degree of risk individuals are willing to accept to receive different types of transplantation procedures, and the risks versus benefits in larynx transplantation.

A 12-year perspective on the world's first total laryngeal transplant.

This effort represents the longest continuous survival of a first organ transplant, when an immunosuppressive regimen was used.

What is the future of ‘organ transplantation’ in the head and neck?

  • D. Lott
  • Medicine
    Current opinion in otolaryngology & head and neck surgery
  • 2014
Significant advancements in tissue engineering have occurred, including the ability to generate three-dimensional tissue structures, which set the foundation to expand reconstructive options for dysfunctional tissues and to improve a patient's quality of life.

Laryngeal transplantation: research, clinical experience, and future goals.

Investigations into the use of irradiation, single-drug and multidrug immunosuppression, and the effects of mammalian target of rapamycin (mTOR) inhibitors have produced significant insight into laryngeal allograft preservation.

Laryngeal transplantation and 40-month follow-up.

Total laryngectomy and total occlusion of the larynx with tracheostomy are associated with an impaired sense of taste and smell, an increased incidence of tracheobronchial infections, stomal

Transplantation of the larynx--a case report that speaks for itself.

  • A. Monaco
  • Medicine
    The New England journal of medicine
  • 2001
This thoughtfully executed application of laryngeal transplantation, initiated after a series of careful experimental studies, is a wonderful example of bench-to-bedside research for which the authors are to be commended.

Laryngeal and tracheal transplantation: ethical limitations.

Over the last decade, there have been extraordinary developments in the field of transplantation science. As a result, organ transplantation enjoys a success that is unparalleled since its

Laryngeal transplantation: ethical considerations.

Laryngeal replacement with an artificial larynx after total laryngectomy: The possibility of restoring larynx functionality in the future

Most patients perceive total laryngectomy as a mutilation carrying with it a loss of physical and psychological integrity. Thus, an artificial larynx system that can replace the laryngeal functions