The cuprizone-induced changes in (1)H-MRS metabolites and oxidative parameters in C57BL/6 mouse brain: Effects of quetiapine.

@article{Xuan2015TheCC,
  title={The cuprizone-induced changes in (1)H-MRS metabolites and oxidative parameters in C57BL/6 mouse brain: Effects of quetiapine.},
  author={Yinghua Xuan and Gen Yan and Renhua Wu and Qing-jun Huang and Xinmin Li and Haiyun Xu},
  journal={Neurochemistry international},
  year={2015},
  volume={90},
  pages={185-92}
}
Cuprizone is a copper-chelating agent and able to induce oligodendrocyte loss and demyelination in C57BL/6 mouse brain. Recent studies have used the cuprizone-fed mouse as an animal model of schizophrenia to examine putative roles of altered oligodendrocytes in this mental disorder. The present study reported the effects of cuprizone on the brain metabolites and oxidative parameters with the aim of providing neurochemical evidence for the application of the cuprizone mouse as an animal model of… CONTINUE READING
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