The culprit drugs in 87 cases of toxic epidermal necrolysis (Lyell's syndrome).


Between 1972 and 1985, 87 patients with toxic epidermal necrolysis (TEN) were admitted to the dermatological intensive care unit at Hôpital Henri Mondor, Créteil, France. The culpable drug was determined by standardized criteria. Only three patients had received no drugs before the onset of TEN. Most patients (71 of 87) were receiving more than one drug. Patients had taken an average of 4.4 +/- 3.4 drugs each. A culpable drug was determined in 67 patients (77%). The mean time from first drug administration to onset of TEN was 13.6 +/- 8.4 days. The culprit drugs included the following: sulfonamides, 18 cases, and especially sulfamethoxazole and trimethoprim, 12; anticonvulsants, seven (barbiturates and carbamazepine only); nonsteroidal anti-inflammatory drugs, 29 (especially the phenylbutazone derivative, 16, and oxicam derivatives, 10); allopurinol, three; chlormezanone, three; and others, seven. Aspirin, antipyretics, and antibiotics are infrequently implicated in this series. The pattern of culprit drugs changed with years. The level of sulfonamide-related TEN remained the same, while incidence of nonsteroidal anti-inflammatory drug-induced TEN increased sharply, the introduction of oxicam derivatives being in part responsible.

Citations per Year

289 Citations

Semantic Scholar estimates that this publication has 289 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Guillaume1987TheCD, title={The culprit drugs in 87 cases of toxic epidermal necrolysis (Lyell's syndrome).}, author={J. C. Guillaume and J. C. Roujeau and Jean E Revuz and Donata Penso and R L Touraine}, journal={Archives of dermatology}, year={1987}, volume={123 9}, pages={1166-70} }