The cullin-RING ubiquitin-protein ligases.

  title={The cullin-RING ubiquitin-protein ligases.},
  author={Zhihua Hua and Richard David Vierstra},
  journal={Annual review of plant biology},
The posttranslational addition of ubiquitin (Ub) helps control the half-life, localization, and action of many intracellular plant proteins. A primary function is the degradation of ubiquitylated proteins by the 26S proteasome, which in turn plays important housekeeping and regulatory roles by removing aberrant polypeptides and various normal short-lived regulators. Strikingly, both genetic and genomic studies reveal that Ub conjugation is extraordinarily complex in plants, with more than 1500… 

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