The crystal structures of eukaryotic phosphofructokinases from baker's yeast and rabbit skeletal muscle.

  title={The crystal structures of eukaryotic phosphofructokinases from baker's yeast and rabbit skeletal muscle.},
  author={Katarzyna Banaszak and Ingrid Mechin and Galina Obmolova and Michael Oldham and Simon H. Chang and Teresa Ruiz and Michael Radermacher and Gerhard Kopperschl{\"a}ger and Wojciech Rypniewski},
  journal={Journal of molecular biology},
  volume={407 2},
Phosphofructokinase 1 (PFK) is a multisubunit allosteric enzyme that catalyzes the principal regulatory step in glycolysis-the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate by ATP. The activity of eukaryotic PFK is modulated by a number of effectors in response to the cell's needs for energy and building blocks for biosynthesis. The crystal structures of eukaryotic PFKs-from Saccharomyces cerevisiae and rabbit skeletal muscle-demonstrate how successive gene duplications… CONTINUE READING
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