The crystal structure of the phosphatidylinositol 4-kinase IIα.

  title={The crystal structure of the phosphatidylinositol 4-kinase IIα.},
  author={Adriana Baumlov{\'a} and Dominika Chalupsk{\'a} and Bartosz R{\'o}życki and Marko Jovi{\'c} and Eva Wisniewski and Martin Kl{\'i}ma and Anna Dubankova and Daniel P Kloer and Radim Nencka and Tamas Balla and Evzen Boura},
  journal={EMBO reports},
  volume={15 10},
Phosphoinositides are a class of phospholipids generated by the action of phosphoinositide kinases with key regulatory functions in eukaryotic cells. Here, we present the atomic structure of phosphatidylinositol 4-kinase type IIα (PI4K IIα), in complex with ATP solved by X-ray crystallography at 2.8 Å resolution. The structure revealed a non-typical kinase fold that could be divided into N- and C-lobes with the ATP binding groove located in between. Surprisingly, a second ATP was found in a… CONTINUE READING