The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand.

@article{Rochel2000TheCS,
  title={The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand.},
  author={N. Rochel and J. Wurtz and A. Mitschler and B. Klaholz and D. Moras},
  journal={Molecular cell},
  year={2000},
  volume={5 1},
  pages={
          173-9
        }
}
The action of 1 alpha, 25-dihydroxyvitamin D3 is mediated by its nuclear receptor (VDR), a ligand-dependent transcription regulator. We report the 1.8 A resolution crystal structure of the complex between a VDR ligand-binding domain (LBD) construct lacking the highly variable VDR-specific insertion domain and vitamin D. The construct exhibits the same binding affinity for vitamin D and transactivation ability as the wild-type protein, showing that the N-terminal part of the LBD is essential for… Expand
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