The crystal structure of the fab fragment of the monoclonal antibody MAK33. Implications for folding and interaction with the chaperone bip.

Abstract

The Fab fragment of the murine monoclonal antibody, MAK33, directed against human creatine kinase of the muscle-type, was crystallized and the three-dimensional structure was determined to 2.9 A. The antigen-binding surface of MAK33 shows a convex overall shape typical for immunoglobulins binding large antigens. The structure allows us to analyze the… (More)

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Cite this paper

@article{Augustine2001TheCS, title={The crystal structure of the fab fragment of the monoclonal antibody MAK33. Implications for folding and interaction with the chaperone bip.}, author={John Augustine and Adelaida de la Calle and Gerhard Knarr and Jens S. Buchner and C A Frederick}, journal={The Journal of biological chemistry}, year={2001}, volume={276 5}, pages={3287-94} }