The crystal structure of the adenylation enzyme VinN reveals a unique β-amino acid recognition mechanism.

Abstract

Adenylation enzymes play important roles in the biosynthesis and degradation of primary and secondary metabolites. Mechanistic insights into the recognition of α-amino acid substrates have been obtained for α-amino acid adenylation enzymes. The Asp residue is invariant and is essential for the stabilization of the α-amino group of the substrate. In contrast… (More)
DOI: 10.1074/jbc.M114.602326

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