The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.

@article{Bravo2001TheCS,
  title={The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.},
  author={Jer{\'o}nimo Bravo and Dimitrios Karathanassis and Christine M Pacold and Michael E Pacold and Chris D. Ellson and Karen E Anderson and P. Jonathan G. Butler and Isabelle Lavenir and Olga Perisic and Phillip T. Hawkins and L. Scott Stephens and Roger L Williams},
  journal={Molecular cell},
  year={2001},
  volume={8 4},
  pages={829-39}
}
More than 50 human proteins with a wide range of functions have a 120 residue phosphoinositide binding module known as the PX domain. The 1.7 A X-ray crystal structure of the PX domain from the p40(phox) subunit of NADPH oxidase bound to PtdIns(3)P shows that the PX domain embraces the 3-phosphate on one side of a water-filled, positively charged pocket and reveals how 3-phosphoinositide specificity is achieved. A chronic granulomatous disease (CGD)-associated mutation in the p47(phox) PX… CONTINUE READING
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