The crystal structure of the C45S mutant of annelid Arenicola marina peroxiredoxin 6 supports its assignment to the mechanistically typical 2-Cys subfamily without any formation of toroid-shaped decamers.

@article{Smeets2008TheCS,
  title={The crystal structure of the C45S mutant of annelid Arenicola marina peroxiredoxin 6 supports its assignment to the mechanistically typical 2-Cys subfamily without any formation of toroid-shaped decamers.},
  author={Aude Smeets and El{\'e}onore Loumaye and Andr{\'e} Clippe and J Rees and Bernard Knoops and J A Declercq},
  journal={Protein science : a publication of the Protein Society},
  year={2008},
  volume={17 4},
  pages={700-10}
}
The peroxiredoxins (PRDXs) define a superfamily of thiol-dependent peroxidases able to reduce hydrogen peroxide, alkyl hydroperoxides, and peroxynitrite. Besides their cytoprotective antioxidant function, PRDXs have been implicated in redox signaling and chaperone activity, the latter depending on the formation of decameric high-molecular-weight structures. PRDXs have been mechanistically divided into three major subfamilies, namely typical 2-Cys, atypical 2-Cys, and 1-Cys PRDXs, based on the… CONTINUE READING
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Crystal structure of the C47S mutant of human peroxiredoxin 5

  • C. Evrard, A. Smeets, B. Knoops, J. P. Declercq
  • J. Chem. Crystallogr. 34: 553–558.
  • 2004
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