The crystal structure of tRNA

  title={The crystal structure of tRNA},
  author={Brian F. C. Clark},
  journal={Journal of Biosciences},
  • B. Clark
  • Published 1 October 2006
  • Chemistry, Medicine
  • Journal of Biosciences
Because of its importance in decoding, its small size (~25 000 Da or 73-93 nucleotides) and its availability, tRNA became a favoured example of a nucleic acid molecule in the 1960s for both sequence determination and 3D-structural elucidation. The fi rst primary structural determination of a tRNA, that of yeast alanine tRNA by Robert Holley’s group at Cornell University (lthaca, NY, USA) in 1965, earned Holley a share in the 1968 Nobel Prize for Physiology or Medicine. By contrast, despite its… 
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