The crystal structure of rabbit phosphoglucose isomerase complexed with 5-phospho-D-arabinonohydroxamic acid.

@article{Arsenieva2002TheCS,
  title={The crystal structure of rabbit phosphoglucose isomerase complexed with 5-phospho-D-arabinonohydroxamic acid.},
  author={Diana Arsenieva and Renaud Hardr{\'e} and Laurent Salmon and C. J. Jeffery},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 9},
  pages={5872-7}
}
Phosphoglucose isomerase (EC ) catalyzes the second step in glycolysis, the reversible isomerization of D-glucose 6-phosphate to D-fructose 6-phosphate. The reaction mechanism involves acid-base catalysis with proton transfer and proceeds through a cis-enediol(ate) intermediate. 5-Phospho-D-arabinonohydroxamic acid (5PAH) is a synthetic small molecule that resembles the reaction intermediate, differing only in that it has a nitrogen atom in place of C1. Hence, 5PAH is the best inhibitor of the… CONTINUE READING