The crystal structure of polygalacturonase-inhibiting protein (PGIP), a leucine-rich repeat protein involved in plant defense

@article{Matteo2003TheCS,
  title={The crystal structure of polygalacturonase-inhibiting protein (PGIP), a leucine-rich repeat protein involved in plant defense},
  author={A. Di Matteo and L. Federici and B. Mattei and G. Salvi and K. Johnson and C. Savino and G. De Lorenzo and D. Tsernoglou and F. Cervone},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100},
  pages={10124 - 10128}
}
Polygalacturonase-inhibiting proteins (PGIPs) are plant cell wall proteins that protect plants from fungal invasion. They interact with endopolygalacturonases secreted by phytopathogenic fungi, inhibit their enzymatic activity, and favor the accumulation of oligogalacturonides, which activate plant defense responses. PGIPs are members of the leucine-rich repeat (LRR) protein family that in plants play crucial roles in development, defense against pathogens, and recognition of beneficial… Expand
An update on polygalacturonase-inhibiting protein (PGIP), a leucine-rich repeat protein that protects crop plants against pathogens
TLDR
The information about the inhibition properties of single pgip gene products against microbial PGs and the results, including field tests, showing the capacity of PGIP to protect crop plants against fungal, oomycetes and bacterial pathogens are updated. Expand
Polygalacturonase-inhibiting protein is a structural component of plant cell wall
TLDR
The data presented here indicate that PGIP, being an extracellular leucine-rich repeat-containing protein, performs important functions in the structure of plant cell wall and may be one of the factors responsible for the set of pathogens causing diseases in a given plant species. Expand
Plant defense mechanisms against fungal pathogens: polygalacturonase inhibitor proteins
TLDR
The high level of polymorphism between both PGIP and PG proteins provides clues toward understanding the functional evolution of plant leucine-rich repeat proteins and their ligands, which will be important for the development of directed disease control strategies for crop protection. Expand
CHARACTERIZATION OF A BETA VULGARIS POLYGALACTURONASE-INHIBITING PROTEIN : A DEFENSE RESPONSE GENE
Polygalacturonase-inhibiting proteins (PGIPs) are plant cell wall proteins that inhibit pathogen and pest polygalacturonases (PGs). PGIPs are members of the leucine-rich repeat (LRR) protein familyExpand
Polygalacturonase-inhibiting proteins--leucine-rich repeat proteins in plant defence.
TLDR
This study reveals that these multigene-encoded defence proteins found in flowering plants only exhibit identical domain architecture with 10 tandemly-arranged LRRs, which implies that variations of PGIP inhibitory properties are not associated with the number of repeats but with subtle changes in the sequence content of the repeats. Expand
Structural Resolution of the Complex between a Fungal Polygalacturonase and a Plant Polygalacturonase-Inhibiting Protein by Small-Angle X-Ray Scattering1[W]
TLDR
The low-resolution structure of the complex formed by the endo-polygalacturonase from Fusarium phyllophilum and one of the polygalACTuronase-inhibiting protein from Phaseolus vulgaris after chemical cross-linking as determined by small-angle x-ray scattering analysis may help the design of inhibitors with improved or new recognition capabilities to be used for crop protection. Expand
Polygalacturonase-inhibiting protein (PGIP) in plant defence: a structural view.
TLDR
A high degree of polymorphism is found both in PGs and PGIPs, accounting for the specificity of different plant inhibitors for PGs from different fungi. Expand
Three aspartic acid residues of polygalacturonase-inhibiting protein (PGIP) from Phaseolus vulgaris are critical for inhibition of Fusarium phyllophilum PG.
TLDR
Mutation of these residues affects the inhibition capacity of PvPGIP2 against F. phyllophilum PG and tests for the inhibitory activity of the mutant proteins expressed in Pichia pastoris against Fusarium phyllophile and Aspergillus niger PGs. Expand
Polygalacturonase inhibiting proteins: players in plant innate immunity?
TLDR
Structural and functional evidence suggest that PGIPs are versatile proteins involved in innate immunity and that they are capable of recognizing different surface motifs of functionally related but structurally variable PGs. Expand
The Polygalacturonase-Inhibiting Protein PGIP2 of Phaseolus vulgaris Has Evolved a Mixed Mode of Inhibition of Endopolygalacturonase PG1 of Botrytis cinerea1
TLDR
The finding that PvPGIP2 inhibits BcPG1 with a mixed-type kinetics further indicates the versatility of PGIPs to evolve different recognition specificities. Expand
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TLDR
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TLDR
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TLDR
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