The crystal structure of insulin I. The investigation of air-dried insulin crystals.

@article{Crowfoot1938TheCS,
  title={The crystal structure of insulin I. The investigation of air-dried insulin crystals.},
  author={Dorothy Crowfoot},
  journal={Proceedings of the Royal Society of London. Series A - Mathematical and Physical Sciences},
  year={1938},
  volume={164},
  pages={580 - 602}
}
  • D. Crowfoot
  • Published 1938
  • Materials Science
  • Proceedings of the Royal Society of London. Series A - Mathematical and Physical Sciences
The crystal structure of insulin is of interest not only in itself but as part of the wider problem of protein structure considered as a whole. The early X-ray work on protein fibres gave strong support to the original chemical theories of the existence of polypeptide chains as the essential backbone of the protein molecule. The comparatively small spacings of 3-4, 4∙5 and 10-11 A which are most prominent on a large section of X-ray photographs of the scleroproteins are easily interpretable in… Expand

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References

SHOWING 1-9 OF 9 REFERENCES
Crystalline Insulin.
  • J. J. Abel
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1926
TLDR
The conclusions of this paper remain substantially unchanged and can be applied equally as well to the reaction between ozone and carbon monoxide, if this reaction be thought responsible for the luminescence. Expand
The Application of the Three‐Dimensional Patterson Method and the Crystal Structures of Proustite, Ag3AsS3, and Pyrargyrite, Ag3SbS3
It is shown that the three‐dimensional Patterson method can be so simplified by the use of the symmetry properties of the crystal under consideration that its use in determining the positions ofExpand
An improved numerical method of two-dimensional fourier synthesis for crystals
It is shown that a two-dimensional Fourier summation for a crystal without a centre of symmetry can be resolved into one-dimensional summations, and these latter can be calculated very rapidly byExpand
Nature , Bond . , 135 , 591 . — 1937 Nature
  • 1935
Nature , Lond . , 127 , 438 . — 1937 a Chem
  • 1931