The crystal structure of an avian IgY-Fc fragment reveals conservation with both mammalian IgG and IgE.

@article{Taylor2009TheCS,
  title={The crystal structure of an avian IgY-Fc fragment reveals conservation with both mammalian IgG and IgE.},
  author={Alexander I Taylor and Stella Fabiane and Brian J. Sutton and Rosaleen A. Calvert},
  journal={Biochemistry},
  year={2009},
  volume={48 3},
  pages={
          558-62
        }
}
Avian IgY is closely related to an ancestor of both mammalian IgG and IgE and thus provides insights into the evolution of antibody structure and function. A recombinant fragment of IgY-Fc consisting of a dimer of the Cupsilon3 and Cupsilon4 domains, Fcupsilon3-4, was expressed and crystallized and its X-ray structure determined to 1.75 A resolution. Fcupsilon3-4 is the only nonmammalian Fc fragment structure determined to date and provides the first structural evidence for an ancient origin of… CONTINUE READING

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