The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage

@article{Scott1995TheCS,
  title={The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage},
  author={William G. Scott and John T. Finch and Aaron Klug},
  journal={Cell},
  year={1995},
  volume={81},
  pages={991-1002}
}
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TLDR
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The structural biology of ribozymes and ribonucleoprotein (RNP) enzymes is now sufficiently advanced that a true dialogue between structural and functional studies is possible. In this review, we
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TLDR
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TLDR
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Modeling active RNA structures using the intersection of conformational space: application to the lead-activated ribozyme.
TLDR
A three-dimensional modeling protocol was used to propose a structure for this ribozyme that suggests an in-line SN2 attack mechanism and predicts two Pb2+ binding sites, and is generally applicable in modeling RNAs whenever the catalytic or binding activity of structural analogues is known.
Construction of hairpin ribozymes with a three-way junction.
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