The crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition.


Hepatocyte growth factor activator inhibitor 1 (HAI-1) is a membrane-bound multidomain protein essential to the integrity of the basement membrane during placental development and is also important in maintaining postnatal homeostasis in many tissues. HAI-1 is a Kunitz-type serine protease inhibitor, and soluble fragments of HAI-1 with variable lengths have… (More)
DOI: 10.1074/jbc.M117.779256