The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase

@article{Su1994TheCS,
  title={The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase},
  author={Xiao-dong Su and Niccolo' Taddei and M. C. Guanziroli Stefani and G. Manao G. Ramponi and Paer Nordlund},
  journal={Nature},
  year={1994},
  volume={370},
  pages={575-578}
}
PROTEIN tyrosine phosphorylation and dephosphorylation are central reactions for control of cellular division, differentiation and development1. Here we describe the crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase (PTPase)2, a cytosolic phosphatase present in many mammalian cells. The enzyme catalyses the dephosphorylation of phosphotyrosine-containing substrates3–6, and overexpression of the protein in normal and transformed cells inhibits cell proliferation7,8… CONTINUE READING
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