The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis.

@article{Wang2010TheCS,
  title={The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis.},
  author={Jing Wang and Stefan Steinbacher and Martin Augustin and Patrick Schreiner and David Epstein and Mark J. Mulvihill and Andrew P A Crew},
  journal={Biochemistry},
  year={2010},
  volume={49 37},
  pages={7972-4}
}
A complex of RON(M1254T) with AMP-PNP and Mg(2+) reveals a substratelike positioning of Tyr1238 as well as likely catalysis-competent placement of the AMP-PNP and Mg(2+) components and indicates a tendency for cis phosphorylation. The structure shows how the oncogenic mutation may cause the constitutive activation and suggests a mechanistic hypothesis for the autophosphorylation of receptor tyrosine kinases.