The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor

@article{Shapiro1998TheCS,
  title={The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor},
  author={Lawrence Shapiro and Philipp E. Scherer},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={335-340}
}

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References

SHOWING 1-10 OF 38 REFERENCES
The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
TLDR
The three-dimensional structure of tumor necrosis factor (TNF-alpha), a protein hormone secreted by macrophages, has been determined and striking structural homology to several viral coat proteins, particularly satellite tobacco necrosis virus is revealed.
Tumor necrosis factor receptor superfamily.
TLDR
The structure of the soluble extracellular domain of TNF-R1 in two crystal forms at pH 3.7 is determined and two distinct structural modules are identified, a type A and a type B module which are suggested to be the unit of structural conservation rather than the 6 cysteine subdomain.
The binding site for C1q on IgG
TLDR
By systematically altering surface residues in the mouse IgG2b isotype, the binding site for C1q is localized to three side chains, Glu 318, Lys 320 and Lys 322, which are relatively conserved in other antibody isotypes and a peptide mimic of this sequence is able to inhibit complement lysis.
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*)
We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte
Chemistry and molecular genetics of C1q.
TLDR
Three other proteins, conglutinin, mannan-binding protein and lung-surfactant protein are structurally similar in many respects to C1q and may also bind to receptors via their collagen-like regions although they show carbohydrate binding properties via their globular 'heads'.
Chemistry and molecular genetics of C1q.
  • K. Reid
  • Biology
    Behring Institute Mitteilungen
  • 1989
TLDR
Three other proteins, conglutinin, mannan-binding protein and lung-surfactant protein are structurally similar in many respects to C1q and may also bind to receptors via their collagen-like regions although they show carbohydrate binding properties via their globular 'heads'.
Collagen-like complement component C1q is a membrane protein of human monocyte-derived macrophages that mediates endocytosis.
TLDR
Interestingly, surface labeling with the biotin derivative sulfosuccinimidyl-6-(biotinamido)-hexanoate of M phi, freshly isolated monocytes, lymphocytes, granulocytes, and myelomonocytic U937 cells revealed that C1q occurs only on the surface of Maphylococcus aureus and appears to be a marker for differentiation into Mphi.
Regulation of synthesis of complement protein C4 in human fibroblasts: cell- and gene-specific effects of cytokines and lipopolysaccharide.
TLDR
Results show that up-regulation by IFN-gamma is a common feature of C2 and C4 expression in human cells that constitutively synthesize these proteins.
...
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