The crystal structure of a Fab fragment to the melanoma-associated GD2 ganglioside.

  title={The crystal structure of a Fab fragment to the melanoma-associated GD2 ganglioside.},
  author={Susan L Pichla and Ramachandran Murali and Roger M. Burnett},
  journal={Journal of structural biology},
  volume={119 1},
The GD2 ganglioside is a cell-surface component that appears on the surface of metastatic melanoma cells and is a marker for the progression of the disease. The ME36.1 monoclonal antibody binds to the GD2 ganglioside and has shown potential as a therapeutic antibody. ME36.1 is a possible alternative therapy to radiation, which is often ineffective in late-stage melanoma. The crystal structure of the Fab fragment of ME36.1 has been determined using molecular replacement and refined to an R… CONTINUE READING

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