The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease.

@article{Honbou2003TheCS,
  title={The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease.},
  author={Kazuya Honbou and Nobuo N. Suzuki and Masataka Horiuchi and Takeshi Niki and Takahiro Taira and Hiroyoshi Ariga and Fuyuhiko Inagaki},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 33},
  pages={31380-4}
}
DJ-1 is a multifunctional protein that plays essential roles in tissues with higher order biological functions such as the testis and brain. DJ-1 is related to male fertility, and its level in sperm decreases in response to exposure to sperm toxicants. DJ-1 has also been identified as a hydroperoxide-responsive protein. Recently, a mutation of DJ-1 was found to be responsible for familial Parkinson's disease. Here, we present the crystal structure of DJ-1 refined to 1.95-A resolution. DJ-1… CONTINUE READING
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