The crystal structure of D7r4, a salivary biogenic amine-binding protein from the malaria mosquito Anopheles gambiae.

@article{Mans2007TheCS,
  title={The crystal structure of D7r4, a salivary biogenic amine-binding protein from the malaria mosquito Anopheles gambiae.},
  author={Ben J Mans and Eric Calvo and Jos{\'e} M C Ribeiro and John Andersen},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 50},
  pages={
          36626-33
        }
}
The D7-related (D7r) proteins of the malaria vector Anopheles gambiae have been shown to bind the biogenic amines serotonin, norepinephrine, and histamine with high affinity. One member of the group (D7r1 or hamadarin) has also been shown to have an anticoagulant/antikinin activity. To understand the mechanistic details of its antihemostatic/anti-inflammatory effects, we have determined the crystal structure of one member of this group, D7r4, along with the structures of ligand complexes with… CONTINUE READING
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