The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor.

@article{Xiang2006TheCS,
  title={The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor.},
  author={Song Xiang and Eun Young Kim and Jessica J Connelly and Nicolas Nassar and Joachim Kirsch and Jan Winking and Guenter Schwarz and Hermann Schindelin},
  journal={Journal of molecular biology},
  year={2006},
  volume={359 1},
  pages={35-46}
}
The synaptic localization of ion channel receptors is essential for efficient synaptic transmission and the precise regulation of diverse neuronal functions. In the central nervous system, ion channel receptors reside in the postsynaptic membrane where they are juxtaposed to presynaptic terminals. For proper function, these ion channels have to be anchored to the cytoskeleton, and in the case of the inhibitory glycine and gamma-amino-butyric acid type A (GABA(A)) receptors this interaction is… CONTINUE READING

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