The crystal structure of ADP-L-glycero-D-mannoheptose 6-epimerase: catalysis with a twist.

@article{Deacon2000TheCS,
  title={The crystal structure of ADP-L-glycero-D-mannoheptose 6-epimerase: catalysis with a twist.},
  author={Ashley Deacon and Yun Ni and William G. Coleman and Steven E. Ealick},
  journal={Structure},
  year={2000},
  volume={8 5},
  pages={453-62}
}
BACKGROUND ADP-L-glycero--mannoheptose 6-epimerase (AGME) is required for lipopolysaccharide (LPS) biosynthesis in most genera of pathogenic and non-pathogenic Gram-negative bacteria. It catalyzes the interconversion of ADP-D-glycero-D-mannoheptose and ADP-L-glycero-D-mannoheptose, a precursor of the seven-carbon sugar L-glycero-mannoheptose (heptose). Heptose is an obligatory component of the LPS core domain; its absence results in a truncated LPS structure resulting in susceptibility to… CONTINUE READING

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