The crystal structure Escherichia coli Spy.

  title={The crystal structure Escherichia coli Spy.},
  author={Eunju Kwon and Dong Young Kim and Carol A. Gross and John D Gross and Kyeong Kyu Kim},
  journal={Protein science : a publication of the Protein Society},
  volume={19 11},
Escherichia coli spheroplast protein y (EcSpy) is a small periplasmic protein that is homologous with CpxP, an inhibitor of the extracytoplasmic stress response. Stress conditions such as spheroplast formation induce the expression of Spy via the Cpx or the Bae two-component systems in E. coli, though the function of Spy is unknown. Here, we report the crystal structure of EcSpy, which reveals a long kinked hairpin-like structure of four α-helices that form an antiparallel dimer. The dimer… CONTINUE READING

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