The cryptic interplay between systemic lupus erythematosus and infections.

@article{Rigante2014TheCI,
  title={The cryptic interplay between systemic lupus erythematosus and infections.},
  author={Donato Rigante and Marta Benedetta Maria Mazzoni and Susanna Esposito},
  journal={Autoimmunity reviews},
  year={2014},
  volume={13 2},
  pages={96-102}
}
The underlying trigger for systemic lupus erythematosus (SLE) has remained elusive, and multiple interacting environmental and genetic factors likely contribute to the onset and perpetuation of the disease. Among environmental influences, infectious agents have been suggested to play a pivotal role in driving autoimmunity pathogenesis via structural or functional molecular mimicry, the expression of proteins that induce cross-reactive responses against self-antigens, and the aberrant activation… CONTINUE READING