The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia.

@article{Vlierberghe2006TheCC,
  title={The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia.},
  author={Pieter Van Vlierberghe and Martine van Grotel and H. Berna Beverloo and Charles Lee and Tryggvi Helgason and Jessica G C A M Buijs-Gladdines and Monique M C J Passier and Elisabeth R van Wering and Anjo J. P. Veerman and Willem A. Kamps and Jules P P Meijerink and Rob Pieters},
  journal={Blood},
  year={2006},
  volume={108 10},
  pages={3520-9}
}
To identify new cytogenetic abnormalities associated with leukemogenesis or disease outcome, T-cell acute lymphoblastic leukemia (T-ALL) patient samples were analyzed by means of the array-comparative genome hybridization technique (array-CGH). Here, we report the identification of a new recurrent and cryptic deletion on chromosome 11 (del(11)(p12p13)) in about 4% (6/138) of pediatric T-ALL patients. Detailed molecular-cytogenetic analysis revealed that this deletion activates the LMO2 oncogene… CONTINUE READING

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