The cryoglobulins: an overview.

  title={The cryoglobulins: an overview.},
  author={Franco Dammacco and Domenico E. Sansonno and Claudia Piccoli and Felicia A Tucci and Vito Racanelli},
  journal={European journal of clinical investigation},
  volume={31 7},
Cryoglobulins are cold-precipitable immunoglobulins associated with a number of infectious, autoimmune and neoplastic disorders. Their appearance along with rheumatoid factor (RF) can be considered a normal event in the clearance of immune complexes and rarely produces any symptoms. The association between hepatitis C virus (HCV) and mixed cryoglobulinemia (MC) has been rendered evident since the recognition of serological markers of HCV infection. There is thus every reason to suppose that… CONTINUE READING
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