The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila

@article{Stanewsky1998TheCM,
  title={The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila},
  author={Ralf Stanewsky and Maki Kaneko and Patrick Emery and Bonnie Beretta and Karen Wager-Smith and Steve A. Kay and Michael Rosbash and Jeffrey C. Hall},
  journal={Cell},
  year={1998},
  volume={95},
  pages={681-692}
}
A new rhythm mutation was isolated based on its elimination of per-controlled luciferase cycling. Levels of period or timeless clock gene products in the mutant are flat in daily light-dark cycles or constant darkness (although PER and TIM oscillate normally in temperature cycles). Consistent with the fact that light normally suppresses TIM, cryb is an apparent null mutation in a gene encoding Drosophila's version of the blue light receptor cryptochrome. Behaviorally, cryb exhibits poor… Expand
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