The crustacean gill (Na+,K+)-ATPase: allosteric modulation of high- and low-affinity ATP-binding sites by sodium and potassium.

@article{Masui2008TheCG,
  title={The crustacean gill (Na+,K+)-ATPase: allosteric modulation of high- and low-affinity ATP-binding sites by sodium and potassium.},
  author={Douglas Chodi Masui and Elias C C Silva and Fernando L Mantelatto and John Campbell McNamara and Hector Barrabin and Helena Maria Scofano and Carlos F L Fontes and Rosa dos Prazeres Melo Furriel and Francisco Assis Leone},
  journal={Archives of biochemistry and biophysics},
  year={2008},
  volume={479 2},
  pages={139-44}
}
The blue crab, Callinectes danae, tolerates exposure to a wide salinity range employing mechanisms of compensatory ion uptake when in dilute media. Although the gill (Na+,K+)-ATPase is vital to hyperosmoregulatory ability, the interactions occurring at the sites of ATP binding on the molecule itself are unknown. Here, we investigate the modulation by Na+ and K+ of homotropic interactions between the ATP-binding sites, and of phosphoenzyme formation of the (Na+,K+)-ATPase from the posterior… CONTINUE READING

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