The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration

@article{Lightman2010TheCR,
  title={The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration},
  author={Stafford L. Lightman and Becky L. Conway-Campbell},
  journal={Nature Reviews Neuroscience},
  year={2010},
  volume={11},
  pages={710-718}
}
The classical concept of hypothalamus–pituitary–adrenal (HPA) homeostasis comprises a feedback system within which circulating levels of glucocorticoid hormones maintain the brain and body in an optimal steady state. However, studies involving new techniques for investigating the real-time dynamics of both glucocorticoid hormones and glucocorticoid receptor function paint a different picture — namely, of continuous dynamic equilibration throughout this neuroendocrine system. This dynamic state… CONTINUE READING
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