The crucial role of mechanical heterogeneity in regulating follicle development and ovulation with engineered ovarian microtissue.

@article{Choi2014TheCR,
  title={The crucial role of mechanical heterogeneity in regulating follicle development and ovulation with engineered ovarian microtissue.},
  author={Jung Kyu Choi and Pranay Agarwal and Haishui Huang and Shuting Zhao and Xiaoming He},
  journal={Biomaterials},
  year={2014},
  volume={35 19},
  pages={5122-8}
}
Contemporary systems for in vitro culture of ovarian follicles do not recapitulate the mechanical heterogeneity in mammalian ovary. Here we report microfluidic generation of biomimetic ovarian microtissue for miniaturized three-dimensional (3D) culture of early secondary preantral follicles by using alginate (harder) and collagen (softer) to fabricate the ovarian cortical and medullary tissues, respectively. This biomimetic configuration greatly facilitates follicle development to antral stage… CONTINUE READING

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