The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model.

@article{Inoue2003TheCR,
  title={The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model.},
  author={Haruhisa Inoue and Kayoko Tsukita and Takuji Iwasato and Yasuyuki Suzuki and Masanori Tomioka and Minako Tateno and Masahiro Nagao and Akihiro Kawata and Takaomi C Saido and Masayuki Miura and Hidemi Misawa and Shigeyoshi Itohara and Ryosuke Takahashi},
  journal={The EMBO journal},
  year={2003},
  volume={22 24},
  pages={6665-74}
}
Mutant copper/zinc superoxide dismutase (SOD1)-overexpressing transgenic mice, a mouse model for familial amyotrophic lateral sclerosis (ALS), provides an excellent resource for developing novel therapies for ALS. Several observations suggest that mitochondria-dependent apoptotic signaling, including caspase-9 activation, may play an important role in mutant SOD1-related neurodegeneration. To elucidate the role of caspase-9 in ALS, we examined the effects of an inhibitor of X chromosome-linked… CONTINUE READING