The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor.


MEK inhibitor has been highlighted as a promising anti-tumor drug but its effect has been reported as varying over a wide range depending on patho-physiological conditions. In this study, we employed a systems approach by combining biochemical experimentation with in silico simulations to investigate the resistance mechanism and functional consequences of… (More)
DOI: 10.1093/jmcb/mjs021


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