The crosslinking theory of aging — Added evidence

@article{Bjorksten1990TheCT,
  title={The crosslinking theory of aging — Added evidence},
  author={Johan Bjorksten and Heikki Tenhu},
  journal={Experimental Gerontology},
  year={1990},
  volume={25},
  pages={91-95}
}

Maillard reaction and aging: can bacteria shed light on the link?

TLDR
Data on the Maillard reaction as a cause of stochastic damage to proteins and DNA implicated in E. coli and human aging is reviewed.

New elements in modern biological theories of aging

TLDR
The principal theories of aging are all specific of a distinct cause of aging, giving useful and deep insights for the understanding of age-related physiological changes.

Non-enzymatic molecular damage as a prototypic driver of aging

TLDR
Endogenous damage accumulation in non-renewable macromolecules and spontaneously polymerized material is sufficient to account for aging and differentiates aging from wear-and-tear of inanimate objects by deriving it from metabolism, the essential attribute of life.

Synthesis, modifications, and turnover of proteins during aging

Why and How Do We Age? A Single Answer to Two Questions

TLDR
Ageing results from the limitations imposed by the immanent physicochemical properties of metabolites on the capabilities and outcomes of the evolution by natural selection; this is what distinguishes aging from the tear and wear of inanimate objects.

Using pentosidine and hydroxyproline to predict age and sex in an avian species

TLDR
Both Ps and HYP increase predictably in cormorants and are predictive of age and breeding status, and given the ubiquity of these biomarkers across taxa, their use in estimating demographic characteristics of animals could provide a powerful tool in animal ecology, conservation, and management.

Human ageing, longevity and evolution: can ageing be programmed?

TLDR
Recent advances in biogerontology that cast new light on these problems are outlined here in the context of the idea that the pace of ageing can act as an adaptation in nature, even though ageing is non-programmed and non-adaptive.

Developmental theory of aging revisited: focus on causal and mechanistic links between development and senescence.

TLDR
The general hypothesis presented herein is a special case of AP that identifies the common cause and mechanism of aging in iteroparous animals and ascribes senescence to unremitting, nonprogrammed change or remodeling forced upon the adult soma by postmaturation expression of developmental gene(s) affecting dynamic transformation of the single-celled conceptus into a complex, multicellular organism.

References

SHOWING 1-10 OF 11 REFERENCES

On the role of cross-linking of cellular proteins in aging

CHEMICAL MECHANISMS UNDERLYING THE BIOLOGICAL MECHANISMS OF THE AGING PROCESS

TLDR
Cross-linkage has an irreversible effect, however, when it happens to form at a point which blocks enzyme action, or at a time when a key event in cell-life takes place (such as an anaphase just after the parallel chromosome DNA molecules have been cross-linked to each other).

FUNDAMENTALS OF AGING: A COMPARISON OF THE MORTALITY CURVE FOR HUMANS WITH A VISCOSITY CURVE OF GELATIN DURING THE CROSS‐LINKING REACTION

TLDR
In view of the mounting evidence in favor of the theory that biologic aging is largely caused by the immobilization of active large molecules, it appeared of interest to compare theshape of a time/viscosity curve of protein immobilization by cross-linkage in vitro with the shape of the mortality curve for humans.

Cross-Linking of Collagen

The formation of collagen cross-links is attributable to the presence of two aldehyde-containing amino acids which react with other amino acids in collagen to generate difunctional, trifunctional,

Aging: a theory based on free radical and radiation chemistry.

TLDR
It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.

Crosslinkage theory of senile cataracts.

TLDR
This paper proposes that crosslinkage is the mechanism for senile cataract formation and recognized as the common denominator in past theories of senileCataracts.

Pressure‐Volume Relation for Cylindrical Tubes with Elastomeric Walls: The Human Aorta

The general theory of the elasticity of elastomers as developed by James and Guth (reference 9) is extended and applied to cylindrical elastomeric tubes. Data obtained by Hallock and Benson