The crosslinking theory of aging — Added evidence

@article{Bjorksten1990TheCT,
  title={The crosslinking theory of aging — Added evidence},
  author={J. Bjorksten and H. Tenhu},
  journal={Experimental Gerontology},
  year={1990},
  volume={25},
  pages={91-95}
}
The crosslinking theory of aging has been gaining acceptance at a steady pace, as evidenced by many independent rediscoveries. While several earlier studies were indicative, none seemed conclusive until it was shown, using Differential Scanning Calorimetry (DSC), that protein from young human brains could be made to closely resemble protein from old brains by exposing it to either of two entirely different crosslinking agents (glutaraldehyde and dipotassium diperoxy sulfate). This work has now… Expand
Maillard reaction and aging: can bacteria shed light on the link?
Abstract Recent studies have debunked the myth about bacterial immortality. Two independent publications, by Stewart et al. (PLoS Biol. 2005;3(2):e45) and Wang et al. (Curr Biol.Expand
New elements in modern biological theories of aging
TLDR
The principal theories of aging are all specific of a distinct cause of aging, giving useful and deep insights for the understanding of age-related physiological changes. Expand
Non-enzymatic molecular damage as a prototypic driver of aging
TLDR
Endogenous damage accumulation in non-renewable macromolecules and spontaneously polymerized material is sufficient to account for aging and differentiates aging from wear-and-tear of inanimate objects by deriving it from metabolism, the essential attribute of life. Expand
Synthesis, modifications, and turnover of proteins during aging
  • S. Rattan
  • Medicine, Chemistry
  • Experimental Gerontology
  • 1996
TLDR
Because posttranslational modifications of proteins determine their activity and stability, alterations in the extent and level of various modifications such as phosphorylation, methylation, ADP-ribosylation, oxidation, glycation, and conformations during aging are being studied. Expand
Why and How Do We Age? A Single Answer to Two Questions
  • A. Golubev
  • Physics, Chemistry
  • Advances in Gerontology
  • 2019
TLDR
Ageing results from the limitations imposed by the immanent physicochemical properties of metabolites on the capabilities and outcomes of the evolution by natural selection; this is what distinguishes aging from the tear and wear of inanimate objects. Expand
Using pentosidine and hydroxyproline to predict age and sex in an avian species
TLDR
Both Ps and HYP increase predictably in cormorants and are predictive of age and breeding status, and given the ubiquity of these biomarkers across taxa, their use in estimating demographic characteristics of animals could provide a powerful tool in animal ecology, conservation, and management. Expand
The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature
  • M. D. Luca
  • Biology
  • Mechanisms of Ageing and Development
  • 2019
TLDR
Recent studies using cell-derived decellularized ECM strongly suggest that age-related changes in the ECM induce cellular senescence, a well-recognized hallmark of aging. Expand
Human ageing, longevity and evolution: can ageing be programmed?
TLDR
Recent advances in biogerontology that cast new light on these problems are outlined here in the context of the idea that the pace of ageing can act as an adaptation in nature, even though ageing is non-programmed and non-adaptive. Expand
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
TLDR
The most promising of them can be AGE inhibitors (chelators, O-acetyl group or transglycating activity compounds, amadorins and amadoriases), glucosepane breakers, stimulators of elastogenesis, and RAGE antagonists. Expand
Developmental theory of aging revisited: focus on causal and mechanistic links between development and senescence.
  • R. Walker
  • Biology, Medicine
  • Rejuvenation research
  • 2011
TLDR
The general hypothesis presented herein is a special case of AP that identifies the common cause and mechanism of aging in iteroparous animals and ascribes senescence to unremitting, nonprogrammed change or remodeling forced upon the adult soma by postmaturation expression of developmental gene(s) affecting dynamic transformation of the single-celled conceptus into a complex, multicellular organism. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 11 REFERENCES
On the role of cross-linking of cellular proteins in aging
TLDR
A molecular basis is proposed for the anti-aging effect of centrophenoxine, which is able to diminish the extent of cross-linking, acting most probably as a free-radical scavenger. Expand
CHEMICAL MECHANISMS UNDERLYING THE BIOLOGICAL MECHANISMS OF THE AGING PROCESS
TLDR
Cross-linkage has an irreversible effect, however, when it happens to form at a point which blocks enzyme action, or at a time when a key event in cell-life takes place (such as an anaphase just after the parallel chromosome DNA molecules have been cross-linked to each other). Expand
FUNDAMENTALS OF AGING: A COMPARISON OF THE MORTALITY CURVE FOR HUMANS WITH A VISCOSITY CURVE OF GELATIN DURING THE CROSS‐LINKING REACTION
TLDR
In view of the mounting evidence in favor of the theory that biologic aging is largely caused by the immobilization of active large molecules, it appeared of interest to compare theshape of a time/viscosity curve of protein immobilization by cross-linkage in vitro with the shape of the mortality curve for humans. Expand
Characterization of proteinaceous material from postmortem human brain by differential scanning calorimetry
Abstract Differential scanning calorimetry, DSC, has been used to investigate the state of water in isolated insoluble proteinaceous fractions from brain tissue of young humans, old humans andExpand
Cross-Linking of Collagen
The formation of collagen cross-links is attributable to the presence of two aldehyde-containing amino acids which react with other amino acids in collagen to generate difunctional, trifunctional,Expand
Aging: a theory based on free radical and radiation chemistry.
  • D. Harman
  • Chemistry, Biology
  • Journal of gerontology
  • 1956
TLDR
It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents. Expand
Crosslinkage theory of senile cataracts.
TLDR
This paper proposes that crosslinkage is the mechanism for senile cataract formation and recognized as the common denominator in past theories of senileCataracts. Expand
Pressure‐Volume Relation for Cylindrical Tubes with Elastomeric Walls: The Human Aorta
The general theory of the elasticity of elastomers as developed by James and Guth (reference 9) is extended and applied to cylindrical elastomeric tubes. Data obtained by Hallock and BensonExpand
DIFFUSION THEORY OF AGING.
...
1
2
...