The cross-talk between osteoclasts and osteoblasts in response to strontium treatment: involvement of osteoprotegerin.

  title={The cross-talk between osteoclasts and osteoblasts in response to strontium treatment: involvement of osteoprotegerin.},
  author={S. Peng and X. Liu and S. Huang and Z. Li and H. Pan and Wanxin Zhen and K. Luk and X. E. Guo and W. Lu},
  volume={49 6},
  • S. Peng, X. Liu, +6 authors W. Lu
  • Published 2011
  • Chemistry, Medicine
  • Bone
  • BACKGROUND The mechanism for the uncoupling effects of Sr on bone remains to be evaluated. Osteoblasts play important roles in osteoclastogenesis through regulating receptor activated nuclear factor kappa B (RANK) ligand (RANKL) and osteoprotegerin (OPG) expression. We hypothesize that OPG plays an important role in the cross-talk between osteoclasts and osteoblasts in response to Sr treatment. MATERIALS AND METHODS MC3T3E1 cells were treated with Sr chloride (0-3 mM) and conditioned media… CONTINUE READING
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