The cross-talk between osteoclasts and osteoblasts in response to strontium treatment: involvement of osteoprotegerin.

@article{Peng2011TheCB,
  title={The cross-talk between osteoclasts and osteoblasts in response to strontium treatment: involvement of osteoprotegerin.},
  author={Songlin Peng and X. Sherry Liu and Shishu Huang and Zhaoyang Li and Haobo Pan and Wanxin Zhen and Keith Kei Dip Luk and X. Edward Guo and Weijia William Lu},
  journal={Bone},
  year={2011},
  volume={49 6},
  pages={
          1290-8
        }
}
BACKGROUND The mechanism for the uncoupling effects of Sr on bone remains to be evaluated. Osteoblasts play important roles in osteoclastogenesis through regulating receptor activated nuclear factor kappa B (RANK) ligand (RANKL) and osteoprotegerin (OPG) expression. We hypothesize that OPG plays an important role in the cross-talk between osteoclasts and osteoblasts in response to Sr treatment. MATERIALS AND METHODS MC3T3E1 cells were treated with Sr chloride (0-3 mM) and conditioned media… CONTINUE READING

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