The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

@article{Luo2013TheCR,
  title={The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies},
  author={Bihui Luo and Amy Si-Ying Lee},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={805-818}
}
Cancer progression is characterized by rapidly proliferating cancer cells that are in need of increased protein synthesis. Therefore, enhanced endoplasmic reticulum (ER) activity is required to facilitate the folding, assembly and transportation of membrane and secretory proteins. These functions are carried out by ER chaperones. It is now becoming clear that the ER chaperones have critical functions outside of simply facilitating protein folding. For example, cancer progression requires… CONTINUE READING
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