The critical role of the loops of triosephosphate isomerase for its oligomerization, dynamics, and functionality.

Abstract

Triosephosphate isomerase (TIM) catalyzes the reaction to convert dihydroxyacetone phosphate into glyceraldehyde 3-phosphate, and vice versa. In most organisms, its functional oligomeric state is a homodimer; however, tetramer formation in hyperthermophiles is required for functional activity. The tetrameric TIM structure also provides added stability to… (More)
DOI: 10.1002/pro.2407

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