The critical role of pathology in the investigation of bioterrorism-related cutaneous anthrax.

@article{Shieh2003TheCR,
  title={The critical role of pathology in the investigation of bioterrorism-related cutaneous anthrax.},
  author={W. J. Shieh and Jeannette Guarner and Christopher D Paddock and Patricia Greer and Kathleen M Tatti and Marc E. Fischer and Marci Layton and Michael Philips and Eddy Bresnitz and Conrad P Quinn and Tanja Popovi{\'c} and Bradley A. Perkins and Sherif R. Zaki},
  journal={The American journal of pathology},
  year={2003},
  volume={163 5},
  pages={1901-10}
}
Cutaneous anthrax is a rare zoonotic disease in the United States. The clinical diagnosis traditionally has been established by conventional microbiological methods, such as culture and gram staining. However, these methods often yield negative results when patients have received antibiotics. During the bioterrorism event of 2001, we applied two novel immunohistochemical assays that can detect Bacillus anthracis antigens in skin biopsy samples even after prolonged antibiotic treatment. These… CONTINUE READING
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