The critical role of glutathione in maintenance of the mitochondrial genome.

@article{Ayer2010TheCR,
  title={The critical role of glutathione in maintenance of the mitochondrial genome.},
  author={Anita Ayer and Shi-Xiong Tan and Chris M Grant and Andreas J Meyer and Ian W. Dawes and Gabriel Perrone},
  journal={Free radical biology & medicine},
  year={2010},
  volume={49 12},
  pages={1956-68}
}
Glutathione (GSH) is a key redox buffer and protectant. Growth (approx. one or two divisions) of cells lacking γ-glutamylcysteine synthetase (gsh1) in the absence of GSH led to irreversible respiratory incompetency in all cells, and after five divisions 75% of cells completely lacked mitochondrial DNA (mtDNA). The level of GSH required to allow continuous growth was distinct from that required to prevent loss of mtDNA. GSH limitation led to a change in the transcript levels of 190 genes… CONTINUE READING