The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.

@article{Takeda2012TheCR,
  title={The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.},
  author={Katsuyuki Takeda and Joshua M Thurman and Stephen Tomlinson and Masakazu Okamoto and Yoshiki Shiraishi and Viviana P. Ferreira and Claudio Cort{\'e}s and Michael K. Pangburn and V. Michael Holers and Erwin W. Gelfand},
  journal={Journal of immunology},
  year={2012},
  volume={188 2},
  pages={661-7}
}
Activation of the alternative pathway of complement plays a critical role in the development of allergen-induced airway hyperresponsiveness (AHR) and inflammation in mice. Endogenous factor H, a potent inhibitor of the alternative pathway, is increased in the airways of sensitized and challenged mice, but its role in regulating inflammation or AHR has been… CONTINUE READING