The critical role of catalase in prooxidant and antioxidant function of p53

@article{Kang2013TheCR,
  title={The critical role of catalase in prooxidant and antioxidant function of p53},
  author={Mi Young Kang and H Kim and C Piao and Ki Hwan Lee and Jin Won Hyun and I-Y Chang and Hye Jin You},
  journal={Cell Death and Differentiation},
  year={2013},
  volume={20},
  pages={117-129}
}
The tumor suppressor p53 is an important regulator of intracellular reactive oxygen species (ROS) levels, although downstream mediators of p53 remain to be elucidated. Here, we show that p53 and its downstream targets, p53-inducible ribonucleotide reductase (p53R2) and p53-inducible gene 3 (PIG3), physically and functionally interact with catalase for efficient regulation of intracellular ROS, depending on stress intensity. Under physiological conditions, the antioxidant functions of p53 are… CONTINUE READING
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