The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.

@article{Sajan2009TheCR,
  title={The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.},
  author={Mini P. Sajan and Mary L. Standaert and S Jonathan Nimal and Usha Varanasi and Tina E. Pastoor and Stephen Mastorides and Ursula Braun and Michael Leitges and Robert V Farese},
  journal={Journal of lipid research},
  year={2009},
  volume={50 6},
  pages={1133-45}
}
Obesity is frequently associated with systemic insulin resistance, glucose intolerance, and hyperlipidemia. Impaired insulin action in muscle and paradoxical diet/insulin-dependent overproduction of hepatic lipids are important components of obesity, but their pathogenesis and inter-relationships between muscle and liver are uncertain. We studied two murine obesity models, moderate high-fat-feeding and heterozygous muscle-specific PKC-lambda knockout, in both of which insulin activation of… CONTINUE READING