The critical role of agrin in the hematopoietic stem cell niche.

@article{Mazzon2011TheCR,
  title={The critical role of agrin in the hematopoietic stem cell niche.},
  author={Cristina Mazzon and Achille Anselmo and Javier Cibella and Cristiana Soldani and Annarita Destro and Natalie Kyung Won Kim and Massimo G. Roncalli and Steven J Burden and Michael L Dustin and Adelaida Sarukh{\'a}n and Antonella Viola},
  journal={Blood},
  year={2011},
  volume={118 10},
  pages={
          2733-42
        }
}
Hematopoiesis is the process leading to the sustained production of blood cells by hematopoietic stem cells (HSCs). Growth, survival, and differentiation of HSCs occur in specialized microenvironments called "hematopoietic niches," through molecular cues that are only partially understood. Here we show that agrin, a proteoglycan involved in the neuromuscular junction, is a critical niche-derived signal that controls survival and proliferation of HSCs. Agrin is expressed by multipotent… CONTINUE READING

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