The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation.

@article{Gardner2012TheCR,
  title={The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation.},
  author={Aaron I Gardner and Andrew J. Fisher and Christine Richter and G. Edward Johnson and Elizabeth J Moisey and Malcolm Brodlie and Christopher Ward and Anja Krippner-Heidenreich and Derek Mann and Lee Anthony Borthwick},
  journal={The American journal of pathology},
  year={2012},
  volume={180 6},
  pages={2293-308}
}
Therapies to limit or reverse fibrosis have proven unsuccessful, highlighting the need for a greater understanding of basic mechanisms that drive fibrosis and, in particular, the link between fibrosis and inflammation. It has been shown that pro-fibrotic transforming growth factor β1 (TGF-β1)-driven epithelial-to-mesenchymal transition (EMT) can be accentuated by tumor necrosis factor α (TNF-α). TGF-β-activated kinase 1 (TAK1) is activated by both TGF-β1 and TNF-α, activating both nuclear… CONTINUE READING
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