The critical role of Fas-Fas ligand interaction in donor-specific transfusion-induced tolerance to H-Y antigen.

@article{Minagawa2004TheCR,
  title={The critical role of Fas-Fas ligand interaction in donor-specific transfusion-induced tolerance to H-Y antigen.},
  author={Ryosuke Minagawa and Shinji Okano and Yukihiro Tomita and Kenji Kishihara and Hisakata Yamada and Kenichi Nomoto and Mitsuo Shimada and Yoshihiko Maehara and Keizo Sugimachi and Yasunobu Yoshikai and Kikuo Nomoto},
  journal={Transplantation},
  year={2004},
  volume={78 6},
  pages={799-806}
}
BACKGROUND Donor-specific transfusion (DST) has been clinically used to enhance the survival of transplanted organs, and it has been shown in mice to induce tolerance to male (H-Y) antigen (Ag). Although the biologic mechanisms that initiate and maintain DST-induced tolerance involve clonal deletion, induction of anergy, and generation of regulatory cells, the molecules essential to tolerance induction are still unclear. In this study, we investigated the role of Fas-FasL interaction in DST… CONTINUE READING