The course of skin involvement in systemic sclerosis over three years in a trial of chlorambucil versus placebo.

@article{Clements1993TheCO,
  title={The course of skin involvement in systemic sclerosis over three years in a trial of chlorambucil versus placebo.},
  author={Philip J. Clements and Peter Anthony Lachenbruch and Daniel e. Furst and Harold E. Paulus},
  journal={Arthritis and rheumatism},
  year={1993},
  volume={36 11},
  pages={1575-9}
}
OBJECTIVE To describe the course of cutaneous involvement in systemic sclerosis (SSc; scleroderma) over 3 years, in the context of a placebo-controlled drug trial. METHODS The course of skin tethering (assessed by a semiquantitative skin scoring technique) was documented annually for 3 years in 64 SSc patients with early (< 3 years duration at entry), intermediate (3-8 years duration), or late (> 8 years duration) diffuse or limited SSc. RESULTS Mean +/- SD entry skin scores were… CONTINUE READING