The coupling of synthesis and partitioning of EBV's plasmid replicon is revealed in live cells

@article{Nanbo2007TheCO,
  title={The coupling of synthesis and partitioning of EBV's plasmid replicon is revealed in live cells},
  author={Asuka Nanbo and Arthur U. Sugden and Bill Sugden},
  journal={The EMBO Journal},
  year={2007},
  volume={26},
  pages={4252 - 4262}
}
Epstein-Barr virus (EBV) is an exceptionally successful human viral pathogen maintained as a licensed, plasmid replicon in proliferating cells. We have measured the distributions of EBV-derived plasmids in single live cells throughout the cell cycle in the absence of selection and confirmed the measured rates of duplication and partitioning computationally and experimentally. These analyses have uncovered a striking, non-random partitioning for this minimalist plasmid replicon and revealed… CONTINUE READING
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